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intéractions moléculaires puces activités


10/12/14 - Article publié par : impact

Publications de la plateforme : 


Béhar G, Pacheco S, Maillasson M, Mouratou B, Pecorari F. Switching an anti-IgG binding site between archaeal extremophilic proteins results in Affitins with enhanced pH stability. J Biotechnol. 2014 Oct 16;192PA:123-129. doi:10.1016/j.jbiotec.2014.10.006. 

Pacheco S, Béhar G, Maillasson M, Mouratou B, Pecorari F. Affinity transfer to the archaeal extremophilic Sac7d protein by insertion of a CDR. Protein Eng Des Sel. 2014 Oct;27(10):431-8. doi: 10.1093/protein/gzu042

Vincent M, Teppaz G, Lajoie L, Solé V, Bessard A, Maillasson M, Loisel S, Béchard D, Clémenceau B, Thibault G, Garrigue-Antar L, Jacques Y, Quéméner A .Highly potent anti-CD20-RLI immunocytokine targeting established human B lymphoma in SCID mouse. MAbs. 2014 Jul-Aug;6(4):1026-37.

Rauscher A, Frindel M, Maurel C, Maillasson M, Le Saëc P, Rajerison H, Gestin JF, Barbet J, Faivre-Chauvet A, Mougin-Degraef M. Influence of pegylation and hapten location at the surface of radiolabelled liposomes on tumourimmunotargeting using bispecific antibody. Nucl Med Biol. 2014 May;41 Suppl:e66-74. doi: 10.1016/j.nucmedbio.2013.12.012. Epub 2013 Dec 26.

Liu H, Queffélec C, Charlier C, Defontaine A, Fateh A, Tellier C, Talham DR, Bujoli B. Design and optimization of a phosphopeptide anchor for specific immobilization of a capture protein on zirconium phosphonate modified supports. Langmuir. 2014 Nov 25;30(46):13949-55. doi: 10.1021/la5036085. Epub 2014 Nov 14. 

2013 :

Feron Delphine, Cathy Charlier , Victor Gourain , Laurent Garderet , Marianne Coste-Burel, Patrice Le Pape, Pierre Weigel, Yannick Jacques, Sylvie Hermouet, Edith Bigot-Corbel. Multiplexed infectious protein microarray immunoassay suitable for the study of the specificity of monoclonal immunoglobulins. Analytical Biochemistry 433 (2013) 202–209

Béhar G, Bellinzoni M, Maillasson M, Paillard-Laurance L, Alzari PM, He X, Mouratou B, Pecorari F. Tolerance of the archaeal Sac7d scaffold protein to alternative library designs: characterization of anti-immunoglobulin G Affitins. Protein Eng Des Sel. 2013 Apr;26(4):267-75. doi:10.1093/protein/gzs106.

Vincent M, Bessard A, Cochonneau D, Teppaz G, Solé V, Maillasson M, Birklé S, Garrigue-Antar L, Quéméner A, Jacques Y. Tumor targeting of the IL-15 superagonist RLI by an anti-GD2 antibody strongly enhances its antitumor potency. Int J Cancer. 2013 Aug 1;133(3):757-65

Daburon S, Devaud C, Costet P, Morello A, Garrigue-Antar L, Maillasson M, Hargous N, Lapaillerie, D, Bonneu M, Dechanet-Merville J, Legembre P, Capone M, Moreau JF, TaupinJL. Functional characterization of a chimeric soluble Fas ligand polymer with in vivo antitumor activity. PLoSOne. 2013;8(1)

Juin P, Geneste O, Gautier F, Depil S, Campone M. Decoding and unlocking the BCL-2 dependency of cancer cells. Nat Rev Cancer. 2013 Jun 20;13(7):455-65

Baud'huin M, Duplomb L, Teletchea S, Lamoureux F, Ruiz-Velasco C, Maillasson M, Redini F, Heymann MF, Heymann D. Osteoprotegerin: Multiple partners for multiple functions. Cytokine Growth Factor Rev. 2013 Jul 1. doi:pii: S1359-6101(13)00059-2.

Rauscher A, Frindel M, Maurel C, Maillasson M, Le Saëc P, Rajerison H, Gestin JF, Barbet J, Faivre-Chauvet A, Mougin-Degraef M. Influence of pegylation and hapten location at the surface of radiolabelled liposomes on tumourimmunotargeting using bispecificantibody.Nucl Med Biol. 2013 Dec 26

Viault G, Babu KS, Gautier F, Barillé-Nion S, Juin P, Tasseau O, Grée R. Hemisynthesis of Selected Embelin Analogues and Investigation of their Proapoptotic Activity Against Cancer Cells. Med Chem. 2013 Jan 28.


2012 :

Vo DD, Gautier F, Juin P, Grée R. Structure-activity relationship of selected polyphenol derivatives as inhibitors of Bax/Bcl-xL interaction. Eur J Med Chem. 2012 May;51:286-93


2011 :

Béhar G,Solé V,Defontaine A, Maillasson M,Quéméner A, Jacques Y, Tellier C. Evolution of interleukin-15 for higher E. coli expression and solubility.Protein Eng Des Sel. 2011 Mar ;24(3):283-90.

Botosoa E. P, Maillasson M, Mougin, Degraef M., Le Saec P., Gestin JF., Jacques Y., Barbet J.,Faivre,Chauvet A. Antibody,Hapten recognition at the surface of functionnalized liposomes studied by SPR : steric hindrance of pegylated phospholipids in stealth liposomes prepared for argeted radionuclide delivery. Journal of drug delivery. 2011

Baud'huin M, Ruiz-Velasco C, Jego G, Charrier C, Gasiunas N, Gallagher J, Maillasson M, Naggi A, Padrines M, Redini F, Duplomb L, Heymann D. Glycosaminoglycans inhibit the adherence and the spreading of osteoclasts and their precursors: role in osteoclastogenesis and bone resorption. Eur J Cell Biol. 2011 Jan;90(1):49-57. 

Velasco CR, Baud'huin M, Sinquin C, Maillasson M, Heymann D, Colliec-Jouault S, Padrines M. Effects of a sulfated exopolysaccharide produced by Altermonasinfernus on bone biology. Glycobiology. 2011 Jun;21(6):781-95. 

2010 :

Martinez SF, Renondo-Cornière A, Nomme J, Eveillard D, Fleury, Takahashi M, Weigel P. Targeting human Rad51 by specific DNA aptamers induces inhibition of homologous recombination. Biochimie. 2010 Aug 13

Venereau E, Diveu C, Grimaud L, Ravon E, Froger J, Preisser L, Danger Y, Maillasson M, Garrigue-Antar L, Jacques Y, Chevalier S, Gascan H. Definition and characterization of an inhibitor for interleukin-31 J Biol Chem. 2010 May 14;285(20):14955-63 


Publications citant la plate-forme:

Levitsky DO, Takahashi M., 2013 - Interplay of Ca(2+) and Mg (2+) in Sodium-Calcium Exchanger and in OtherCa(2+)-Binding Proteins: Magnesium, Watchdog That Blocks Each Turn ifAble. AdvExp Med Biol. 2013;961:65-78. doi: 10.1007/978-1-4614-4756-6_7

Nomme J, Renondo-Cornière A, Asanomi Y, Sakaguchi K, Stasiak AZ, Stasiak A, Norden B, Tran V, Takahashi M. Design of potent inhibitors of human RAD51 recombinase based on BRC motifs of BRCA2
protein: modeling and experimental validation of a chimera peptide. J Med Chem. 2010 Aug 2;53(15):5782-91.

Slupianek A., Dasgupta Y., Ren S., Gurdek E., Bargaonu M., Nieborowska-Skorska B., Fleury F.,Skorski T. (2011). Targeting RAD51 phosphotyrosine-315 to prevent unfaithful homeologous recombination repair in BCT-ABL1 leukemia, Blood, 118(4) : 1062-8.

Popova M., Henry S., Fleury F. (2011) Posttranslational modifications of Rad51 protein and its direct partners : role and effect on Homologous Recombination - mediated DNA repair. Chapitred’ouvrage "DNA Repair/Book 4", ISBN 978-953-307-1336-0, pp.143-160.

Féron M.,Rouger K., Guével L. (2011). "Proteomic analysis of signalling pathway deregulation in dystrophic dog muscle". Book " Muscular Dystrophy",ISBN979-953-307-200-4

Miranda F.F., Brient-Litzler E., Zidane N., Pecorari F., Bedouelle H. (2011) Reagentless fluorescent biosensors from artificial families of antigen binding proteins Biosensors and Bioelectronics

Guével,L., Lavoie J., Perez-Iratxeta C., Rouger K., Dubreil L.,Feron M., Talon S., Brand M. Megeney L. (2011) : "Quantitative proteomic analysis of dystrophic dog muscle", Journal of Proteome Research

Fornander L, Frykholm K, Reymer A, Renodon-Cornière A, Takahashi M,Norden B. (2012) :
"Ca2+ improves organization of single-stranded DNA bases in human Rad51 filament, explaining
stimularoty effect on gene recombination", Nucleic Acids Research.

 Cinier M, Petit M,Pecorari F,Talham DR, Bujoli B,Tellier C. (2012): Engineering of a phosphorylatable tag for specific protein binding on zirconium phosphonate based microarrays, J BiolInorg Chem.

Mary C, Coulon F, Poirier N, Dilek N, Martinet B, Blancho G, Vanhove B. Antagonist properties of monoclonal antibodies targeting human CD28: role of valency and the heavy-chain constant domain. MAbs. 2013 Jan-Feb;5(1):47-55. doi: 10.4161/mabs.22697. Epub 2012 Dec 5.